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The interaction between DAP1 and autophagy in the context of human carcinogenesis

Wazir, Umar, Khanzada, Zubair S., Jiang, Wen Guo, Sharma, Anup K., Kasem, Abdul and Mokbel, Kefah 2014. The interaction between DAP1 and autophagy in the context of human carcinogenesis. Anticancer Research 34 (1) , pp. 1-8.

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Autophagy is an evolutionarily-conserved catabolic process which furthers cell survival, especially in times of nutritional stress. Whilst being by itself a pro-survival mechanism, it has many areas of overlap with apoptosis. Autophagic cell death is recognised as a subset of programmed cell death, with features more typical of autophagy rather than classical apoptosis. The mechanisms preventing autophagy from unravelling into autophagic cell death are still the subject of much controversy. We discuss the current understanding of these mechanisms, including recent research regarding the role of death-associated protein-1 in autophagy and apoptosis.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Publisher: International Institute of Anticancer Research
ISSN: 0250-7005
Date of Acceptance: 3 December 2013
Last Modified: 05 Jun 2019 14:28

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