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Huntingtin localisation studies - a technical review

Hughes, Alis and Jones, Lesley 2011. Huntingtin localisation studies - a technical review. Plos Currents 3 , RRN1211. 10.1371/currents.RRN1211

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It is well recognised that there are pitfalls when defining the subcellular localisation of a protein with immunocytochemistry. Accurate protein localisation to particular cellular micro-architecture is crucial in defining its role within the cell. Huntingtin (HTT), the protein mutated in the neurodegenerative disorder Huntington’s disease (HD) is a large protein of ill-defined function. Bearing little resemblance to other proteins, its function has been difficult to assign, therefore localising this protein with precision within the cell may provide further clues as to its normal and pathological function. Lack of consistency between methods employed in different studies has resulted in varying conclusions as to its subcellular localisation. This technical review investigates the effects that different immunocytological methods can have upon the apparent subcellular localisation of the huntingtin protein, and discusses the implications this may have.

Item Type: Article
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects: R Medicine > R Medicine (General)
Publisher: Public Library of Science
ISSN: 2157-3999
Last Modified: 23 Jan 2018 20:48

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