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Pre-pubertal stress and brain development in rodents

Brydges, Nichola Marie 2016. Pre-pubertal stress and brain development in rodents. Current Opinion in Behavioral Sciences 7 , pp. 8-14. 10.1016/j.cobeha.2015.08.003

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Abstract

Exposure to adversity early in life is associated with the development of a range of psychiatric disorders in adulthood. Accumulating evidence suggests that pre-puberty is a time of enhanced vulnerability to environmental insults, and that pre-pubertal stress may alter normal brain maturation. In this review, I consider the long-term consequences of pre-pubertal stress on brain and behaviour in rodent models. Recent studies support the notion that pre-puberty is a time of enhanced vulnerability to stress, with particular consequences for the limbic system. Alterations in epigenetic mechanisms are likely to be responsible for the maintenance of enduring modifications in brain and behaviour after experience of pre-pubertal stress.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > R Medicine (General)
Additional Information: Available online 19 August 2015
Publisher: Elsevier
ISSN: 2352-1546
Date of First Compliant Deposit: 30 March 2016
Date of Acceptance: 10 August 2015
Last Modified: 17 Jun 2019 08:59
URI: http://orca.cf.ac.uk/id/eprint/76246

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