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The natural history of eczema from birth to adult life: a cohort study

Burr, Michael Leslie, Dunstan, Frank David, Hand, Sadiyah, Ingram, John Robert and Jones, K. 2013. The natural history of eczema from birth to adult life: a cohort study. British Journal of Dermatology 168 (6) , pp. 1339-1342. 10.1111/bjd.12216

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Abstract

Background Eczema is common in infancy; however, there is little evidence about its natural history to adulthood. Objectives To study the natural history of eczema from birth to young adult life with particular reference to its relation to atopy. Methods A birth cohort of children with atopic family histories was followed for 23 years. Clinical examinations were conducted until the age of 7 years, skin-prick tests and serum total IgE were recorded in infancy and at ages 7 and 23 years, and questionnaires about eczema symptoms were completed at 15 and 23 years. Results Information was obtained on 497 subjects at birth, 482 at 1 year, 440 at 7 years, 363 at 15 years and 304 at 23 years. Eczema usually remitted from age 1 to 7 years but became more persistent from the age of 15 years, especially in those who were atopic. The prevalence of eczema rose in women from age 15 to 23 years but declined in men. Adults with eczema had higher IgE than those without at 3 months (geometric mean 3·0 vs. 1·7 kU L-1; P = 0·01), 7 years (107·9 vs. 45·2 kU L-1; P = 0·01) and 23 years (123·4 vs. 42·3 kU L-1; P = 0·01), and were more likely to have had positive skin-prick tests at 1 year of age. Current eczema was associated with raised IgE in infancy and adulthood but not in childhood. Conclusions Predisposed infants and children with eczema usually grow out of the disease, but in adolescence it is more likely to persist. Adult eczema is related to atopy from the age of 3 months. What's already known about this topic? Eczema is associated with atopy, asthma and rhinoconjunctivitis. Eczema in infancy usually remits but is more likely to persist if the child is atopic. After puberty eczema often persists to adult life. What does this study add? Adult eczema is associated with atopy from the age of 3 months. Atopy increases the likelihood of persistence after adolescence.

Item Type: Article
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
R Medicine > RZ Other systems of medicine
Uncontrolled Keywords: Adolescent; Age Factors; Child; Child, Preschool; Cohort Studies; Eczema; Female; Follow-Up Studies; Humans; Immunoglobulin E; Infant; Male; Prevalence; Questionnaires; Severity of Illness Index; Sex Factors; Skin Tests; Young Adult
Publisher: Wiley-Blackwell
ISSN: 0007-0963
Last Modified: 23 Dec 2017 20:56
URI: http://orca.cf.ac.uk/id/eprint/76567

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