Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Genome-wide association study of co-occurring anxiety in major depression

Schosser, Alexandra, Butler, Amy W., Uher, Rudolf, Ng, Mandy Y., Cohen-Woods, Sarah, Craddock, Nicholas John, Owen, Michael John, Korszun, Ania, Gill, Michael, Rice, John, Hauser, Joanna, Henigsberg, Neven, Maier, Wolfgang, Mors, Ole, Placentino, Anna, Rietschel, Marcella, Souery, Daniel, Preisig, Martin, Craig, Ian W., Farmer, Anne E., Lewis, Cathryn M. and McGuffin, Peter 2013. Genome-wide association study of co-occurring anxiety in major depression. World Journal of Biological Psychiatry 14 (8) , pp. 611-21. 10.3109/15622975.2013.782107

Full text not available from this repository.

Abstract

Objectives. Co-morbidity between depression and anxiety disorders is common. In this study we define a quantitative measure of anxiety by summating four anxiety items from the SCAN interview in a large collection of major depression (MDD) cases to identify genes contributing to this complex phenotype. Methods. A total of 1522 MDD cases dichotomised according to those with at least one anxiety item scored (n = 1080) and those without anxiety (n = 442) were analysed, and also compared to 1588 healthy controls at a genome-wide level, to identify genes that may contribute to anxiety in MDD. Results. For the quantitative trait, suggestive evidence of association was detected for two SNPs, and for the dichotomous anxiety present/absent ratings for three SNPs at genome-wide level. In the genome-wide analysis of MDD cases with co-morbid anxiety and healthy controls, two SNPs attained P values of < 5 × 10–6. Analysing candidate genes, P values ≤ 0.0005 were found with three SNPs for the quantitative trait and three SNPs for the dichotomous trait. Conclusions. This study provides an initial genome-wide assessment of possible genetic contribution to anxiety in MDD. Although suggestive evidence of association was found for several SNPs, our findings suggest that there are no common variants strongly associated with anxious depression.

Item Type: Article
Date Type: Publication
Status: Published
Schools: MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Medicine
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > R Medicine (General)
Publisher: Informa Healthcare
ISSN: 1562-2975
Last Modified: 23 Dec 2017 20:58
URI: http://orca.cf.ac.uk/id/eprint/76697

Citation Data

Cited 7 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item