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Chemoselective N-deacetylation of protected nucleosides and nucleotides promoted by the Schwartz's reagent

Ferrari, Valentina, Serpi, Michaela, McGuigan, Christopher and Pertusati, Fabrizio 2015. Chemoselective N-deacetylation of protected nucleosides and nucleotides promoted by the Schwartz's reagent. Nucleosides, Nucleotides & Nucleic Acids 34 (11) , pp. 799-814. 10.1080/15257770.2015.1075552

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Abstract

Protection and deprotection strategies involving the N-acetyl group are widely utilized in nucleoside and nucleotide chemistry. Herein, we present a mild and selective N-deacetylation methodology, applicable to purine and pyrimidine nucleosides, by means of Schwartz's reagent, compatible with most of the common protecting groups used in nucleoside chemistry.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Pharmacy
Systems Immunity Research Institute (SIURI)
Subjects: R Medicine > RM Therapeutics. Pharmacology
Additional Information: Published online: 22 Oct 2015 This is an Open Access article. Non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly attributed, cited, and is not altered, transformed, or built upon in any way, is permitted
Publisher: Taylor & Francis
ISSN: 1525-7770
Date of First Compliant Deposit: 30 March 2016
Date of Acceptance: 20 July 2015
Last Modified: 24 Oct 2017 23:17
URI: http://orca.cf.ac.uk/id/eprint/77077

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