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Extracellular vesicles as modulators of the cancer microenvironment

Webber, Jason P., Yeung, Vincent and Clayton, Aled 2015. Extracellular vesicles as modulators of the cancer microenvironment. Seminars in Cell and Developmental Biology 40 , pp. 27-34. 10.1016/j.semcdb.2015.01.013

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Abstract

The tumour microenvironment is a highly complex and dynamic tissue. It comprises not only neoplastic cells, but also other resident cells within the milieu such as stroma and vascular cells in addition to a variable cellular infiltrate from the periphery. A host of soluble factors such as growth factors, chemokines, eicosanoids soluble metabolites and extracellular matrix components have been extensively documented as factors which modulate this environment. However, in recent years there has also been growing interests in the potential roles of extracellular vesicles (EV) in many of the processes governing the nature of cancerous tissue. In this brief review, we have assembled evidence describing several distinct functions for extracellular vesicles in modulating the microenvironment with examples that include immune evasion, angiogenesis and stromal activation. Whilst there remains a great deal to be learnt about the interplay between vesicles and the cancerous environment, it is becoming clear that vesicle-mediated communication has a major influence on key aspects of cancer growth and progression. We conclude that the design of future therapeutics should acknowledge the existence and roles of extracellular vesicles, and seriously consider strategies for circumventing their effects in vivo.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Additional Information: Available online 7 February 2015
Publisher: Elsevier
ISSN: 1084-9521
Funders: CRW, Ser Cymru, Movember, Prostate Cancer UK, BLF
Last Modified: 28 Jun 2019 02:30
URI: http://orca.cf.ac.uk/id/eprint/77253

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