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Evidence of an autocrine role for leptin and leptin receptor in human breast cancer

Wazir, Umar, Al Sarakbi, Wael, Jiang, Wen Guo and Mokbel, Kefah 2012. Evidence of an autocrine role for leptin and leptin receptor in human breast cancer. Cancer Genomics and Proteomics 9 (6) , pp. 383-387.

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Abstract

We studied potential associations between the expression of leptin, leptin receptor (LEPR) and clinicopathological parameters of breast cancer, and the correlation of leptin with human telomerase reverse transcriptase (hTERT) and cyclooxygenase 2 (COX2) A total of 153 specimens were studied. Transcript levels were determined using quantitative polymerase chain reaction (qPCR), and were correlated with clinicopathological data collected for over 10 years. Additionally, leptin and LEPR expression was studied in several breast cell lines. Both leptin and LEPR mRNA expression were higher in malignant samples (p=0.0011 and 0.0014 respectively). Both were also expressed in MDA436 and MCF7 cell lines. Leptin showed a significant correlation with LEPR (r=0.504, p=0.0000000222). Leptin did not correlate significantly with clinical stage, tumour grade, or with the expression of hTERT or COX2. This study demonstrates that leptin and LEPR are more readily expressed in cancerous tissues suggesting a possible autocrine role in mammary carcinogenesis, which may be independent of hTERT and COX2 genes. Evidence of an autocrine role for leptin and leptin receptor in human breast cancer - ResearchGate. Available from: http://www.researchgate.net/publication/233539263_Evidence_of_an_autocrine_role_for_leptin_and_leptin_receptor_in_human_breast_cancer [accessed Oct 9, 2015].

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Publisher: International Institute of Anticancer Research
ISSN: 1109-6535
Related URLs:
Last Modified: 04 Jun 2017 08:24
URI: http://orca.cf.ac.uk/id/eprint/77495

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