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Plasmid carriage of blaNDM-1 in clinical Acinetobacter baumannii isolates from India

Jones, Lim Stephen, Toleman, Mark, Weeks, Janis, Howe, Robin, Walsh, Timothy Rutland and Kumarasamy, Karthikeyan K. 2014. Plasmid carriage of blaNDM-1 in clinical Acinetobacter baumannii isolates from India. Antimicrobial Agents and Chemotherapy 58 (7) , pp. 4211-4213. 10.1128/AAC.02500-14

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NDM-1 probably emerged in Acinetobacter species prior to its dissemination among Enterobacteriaceae, and NDM-1-like enzymes are increasingly reported in Acinetobacter species. Here, we report on the genetic context of blaNDM-1 in the earliest known NDM-1-producing organisms, clinical isolates of Acinetobacter from India in 2005. These strains harbor blaNDM-1 plasmids of different sizes. The gene is associated with the remnants of the Tn125 transposon normally associated with blaNDM-1 in Acinetobacter spp. The transposon has been disrupted by the IS26 insertion and subsequent movement events.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Systems Immunity Research Institute (SIURI)
Subjects: Q Science > QR Microbiology
Publisher: American Society for Microbiology
ISSN: 0066-4804
Date of Acceptance: 13 April 2014
Last Modified: 06 Feb 2019 17:05

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Cited 9 times in Web of Science. View in Web of Science.

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