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The transcription factor Gata6 links tissue macrophage phenotype and proliferative renewal

Rosas, Marcela, Davies, Luke, Giles, Peter, Liao, Chia-Te, Kharfan, Bashar, Stone, Timothy, O'Donnell, Valerie, Fraser, Donald, Jones, Simon and Taylor, Philip Russel 2014. The transcription factor Gata6 links tissue macrophage phenotype and proliferative renewal. Science 344 (6184) , pp. 645-648. 10.1126/science.1251414

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Abstract

Tissue-resident macrophages are heterogeneous as a consequence of anatomical niche–specific functions. Many populations self-renew independently of bone marrow in the adult, but the molecular mechanisms of this are poorly understood. We determined a transcriptional profile for the major self-renewing population of peritoneal macrophages in mice. These cells specifically expressed the transcription factor Gata6. Selective deficiency of Gata6 in myeloid cells caused substantial alterations in the transcriptome of peritoneal macrophages. Gata6 deficiency also resulted in dysregulated peritoneal macrophage proliferative renewal during homeostasis and in response to inflammation, which was associated with delays in the resolution of inflammation. Our investigations reveal that the tissue macrophage phenotype is under discrete tissue-selective transcriptional control and that this is fundamentally linked to the regulation of their proliferation renewal.

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Medicine
Systems Immunity Research Institute (SIURI)
Subjects: R Medicine > R Medicine (General)
Additional Information: PDf uploaded in accordance with publisher's policies (http://www.sherpa.ac.uk/romeo/issn/0036-8075/ )accessed 23.10.15.
Publisher: American Association for the Advancement of Science
ISSN: 0036-8075
Date of First Compliant Deposit: 30 March 2016
Date of Acceptance: 11 April 2014
Last Modified: 20 Jun 2019 20:37
URI: http://orca.cf.ac.uk/id/eprint/78545

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