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Impact of FLT3ITD mutant allele level on relapse risk in intermediate-risk acute myeloid leukemia

Linch, David C., Hills, Robert, Burnett, Alan K., Khwaja, Asim and Gale, Rosemary E. 2014. Impact of FLT3ITD mutant allele level on relapse risk in intermediate-risk acute myeloid leukemia. Blood 124 (2) , pp. 273-276. 10.1182/blood-2014-02-554667

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Some studies have suggested that cases of acute myeloid leukemia (AML) with low levels of FLT3 internal tandem duplications (FLT3ITD) do not have a worse prognosis if there is a concomitant NPM1 mutation, although this is controversial. To clarify this therapeutically important issue, we have analyzed FLT3ITD and NPM1MUT levels in 1609 younger adult cases of cytogenetically intermediate-risk AML. The cumulative incidence of relapse was increased in NPM1MUT cases by the presence of a FLT3ITD, but did not differ markedly according to FLT3ITD level. This remained true when allowance was made for poor leukemic cell purity by adjustment of the FLT3ITD level to the measured NPM1MUT level. If consolidation therapies are to be determined by relapse risk, then NPM1MUT cases with low-level FLT3ITD should not be considered as good risk without further studies. AML 12 and AML 15 are registered at under ISRCTN17833622 and ISRCTN17161961, respectively.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Publisher: American Society of Hematology
ISSN: 0006-4971
Date of Acceptance: 12 May 2014
Last Modified: 19 Oct 2019 03:00

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