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Assessing the activity of microbicides against bacterial spores: knowledge and pitfalls

Leggett, Mark J., Setlow, Peter, Sattar, Syed and Maillard, Jean-Yves 2016. Assessing the activity of microbicides against bacterial spores: knowledge and pitfalls. Journal of Applied Microbiology 120 (5) , pp. 1174-1180. 10.1111/jam.13061

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Abstract

Bacterial endospores (spores) have a higher intrinsic resistance to microbicides as compared to other microbial forms, most likely due to their impermeable outer layers and low water content. Though structural differences between the spores of various bacterial species may account for observed variations in their resistance to microbicides, flaws in methods for testing the sporicidal activity of microbicides often exaggerate the differences. This has major implications when considering the selection of one or more surrogates to assess microbicides against clinically relevant spore-formers such as Clostridium difficile. The mounting significance of C. difficile as a pathogen is leading to a corresponding increase in the number of commercially available microbicidal formulations claiming activity against its spores without proper differentiation between the product's sporistatic and sporicidal actions. In this review we critically assess the situation and the implications of product claims on the field use of microbicidal products

Item Type: Article
Date Type: Publication
Status: Published
Schools: Pharmacy
Subjects: R Medicine > RM Therapeutics. Pharmacology
Additional Information: Pdf uploaded in accordance with publisher's policy at http://www.sherpa.ac.uk/romeo/issn/1364-5072/ (accessed 22/06/2016)
Publisher: Wiley
ISSN: 1364-5072
Date of First Compliant Deposit: 30 March 2016
Date of Acceptance: 14 October 2015
Last Modified: 05 Jun 2017 05:39
URI: http://orca.cf.ac.uk/id/eprint/78691

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