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Clinical experience of IL-6 blockade in rheumatic diseases: implications on IL-6 biology and disease pathogenesis

Davies, Ruth and Choy, Ernest 2014. Clinical experience of IL-6 blockade in rheumatic diseases: implications on IL-6 biology and disease pathogenesis. Seminars in Immunology 26 (1) , pp. 97-104. 10.1016/j.smim.2013.12.002

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Abstract

Interleukin 6 (IL-6) plays a significant role in many rheumatological diseases and has been described as both a pro- and anti-inflammatory cytokine. IL-6 blockade has been investigated in various rheumatic diseases and a humanised anti-IL-6 receptor antibody has been licensed for use in rheumatoid arthritis, systemic and polyarticular juvenile idiopathic arthritis. The increasing clinical experience of IL-6 blockade in rheumatic diseases adds to the existing knowledge regarding the physiological and pathological roles of IL-6.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: Q Science > QR Microbiology > QR180 Immunology
Publisher: Elsevier
ISSN: 1044-5323
Last Modified: 08 Jan 2020 04:49
URI: http://orca.cf.ac.uk/id/eprint/79199

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