Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Acute kidney injury: a paradigm for miRNA regulation of the cell cycle

Khalid, Usman, Bowen, Timothy, Fraser, Donald and Jenkins, Robert 2014. Acute kidney injury: a paradigm for miRNA regulation of the cell cycle. Biochemical Society Transactions 42 (4) , pp. 1219-1223. 10.1042/BST20140093

Full text not available from this repository.

Abstract

miRNAs are small, endogenous, post-transcriptional regulators of gene expression. AKI (acute kidney injury) of various aetiologies, including trauma, sepsis and IRI (ischaemia/reperfusion injury) in the context of kidney transplantation, or drug toxicity, has a high morbidity and mortality rate and presents a significant burden to health services worldwide. AKI primarily affects the renal cortex, in particular PTCs (proximal tubular epithelial cells). Current research demonstrates causality between G2/M cell cycle arrest of PTCs and AKI. Recent findings from our laboratory and others presented in this review implicate miRNA regulation of the cell cycle in the pathology of AKI.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Systems Immunity Research Institute (SIURI)
Subjects: R Medicine > R Medicine (General)
Publisher: Portland Press
ISSN: 0300-5127
Last Modified: 23 Nov 2017 21:21
URI: http://orca.cf.ac.uk/id/eprint/79250

Citation Data

Cited 7 times in Google Scholar. View in Google Scholar

Cited 15 times in Scopus. View in Scopus. Powered By Scopus® Data

Cited 3 times in Web of Science. View in Web of Science.

Actions (repository staff only)

Edit Item Edit Item