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New heteronuclear gold(I)-platinum(II) complexes with cytotoxic properties: Are two metals better than one?

Wenzel, Margot, Bigaeva, Emilia, Richard, Philippe, Le Gendre, Pierre, Picquet, Michel, Casini, Angela and Bodio, Ewen 2014. New heteronuclear gold(I)-platinum(II) complexes with cytotoxic properties: Are two metals better than one? Journal of Inorganic Biochemistry 141 , pp. 10-16. 10.1016/j.jinorgbio.2014.07.011

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Abstract

A series of mono- and heterodinuclear gold(I) and platinum(II) complexes with a new bipyridylamine-phosphine ligand have been synthesized and characterized. The X-ray structures of the ligand precursor 4-iodo-N,N-di(pyridin-2-yl)benzamide, and of one gold derivative are reported. All the complexes display antiproliferative properties in vitro in human cancer cells in the range of cisplatin or higher, which appear to correlate with compounds' uptake. Interestingly, studies of the interactions of the compounds with models of DNA indicate different mechanisms of actions with respect to cisplatin. The biological activity study of these complexes provides useful information about the interest of designing multimetallic complexes for enhanced cytotoxic properties.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Subjects: Q Science > QD Chemistry
Uncontrolled Keywords: Heteronuclear complex; Gold complex; Platinum complex; Anticancer agent; Thioglucose
Publisher: Elsevier
ISSN: 0162-0134
Date of First Compliant Deposit: 1 November 2016
Date of Acceptance: 14 July 2014
Last Modified: 04 Jun 2017 08:30
URI: http://orca.cf.ac.uk/id/eprint/79293

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