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Caffeine-based gold(I) N-heterocyclic carbenes as possible anticancer agents: synthesis and biological properties

Bertrand, Benoit, Stefan, Loic, Pirrotta, Marc, Monchaud, David, Bodio, Ewen, Richard, Philippe, Le Gendre, Pierre, Warmerdam, Elena, de Jager, Marina H., Groothuis, Geny M. M., Picquet, Michel and Casini, Angela 2014. Caffeine-based gold(I) N-heterocyclic carbenes as possible anticancer agents: synthesis and biological properties. Inorganic Chemistry 53 (4) , pp. 2296-2303. 10.1021/ic403011h

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Abstract

Organometallic Au(I) NHC compounds bearing caffeine-type ligands have been synthesized and characterized as promising anticancer agents. The bis-carbene complex [Au(caffeine-2-yliene)2][BF4] appeared to be selective for human ovarian cancer cell lines in vitro and poorly toxic in healthy organs ex vivo. The compound shows high affinity and selectivity for G-quadruplex structures as demonstrated by FRET melting assay.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Subjects: Q Science > QD Chemistry
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Publisher: American Chemical Society
Last Modified: 25 Feb 2019 11:23
URI: http://orca.cf.ac.uk/id/eprint/79306

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