Application of mass spectrometric techniques to delineate the modes-of-action of anticancer metallodrugs

Hartinger, Christian G., Groessl, Michael, Meier, Samuel M., Casini, Angela ORCID: https://orcid.org/0000-0003-1599-9542 and Dyson, Paul J. 2013. Application of mass spectrometric techniques to delineate the modes-of-action of anticancer metallodrugs. Chemical Society Reviews 42 (14) , pp. 6186-6199. 10.1039/C3CS35532B

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Abstract

Mass spectrometry (MS) has emerged as an important tool for studying anticancer metallodrugs in complex biological samples and for characterising their interactions with biomolecules and potential targets on a molecular level. The exact modes-of-action of these coordination compounds and especially of next generation drug candidates have not been fully elucidated. Due to the fact that DNA is considered a crucial target for platinum chemotherapeutics, metallodrug–DNA binding studies dominated the field for a long time. However, more recently, alternative targets were considered, including enzymes and proteins that may play a role in the overall pharmacological and toxicological profile of metallodrugs. This review focuses on MS-based techniques for studying anticancer metallodrugs in vivo, in vitro and in situ to delineate their modes-of-action.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Chemistry
Subjects:	Q Science > QD Chemistry R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Publisher:	Royal Society of Chemistry
ISSN:	0306-0012
Last Modified:	31 Oct 2022 08:57
URI:	https://orca.cardiff.ac.uk/id/eprint/79316

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