Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Interactions of anticancer Pt compounds with proteins: An overlooked topic in medicinal inorganic chemistry?

Casini, Angela and Reedijk, Jan 2012. Interactions of anticancer Pt compounds with proteins: An overlooked topic in medicinal inorganic chemistry? Chemical Science 3 (11) , pp. 3135-3144. 10.1039/C2SC20627G

Full text not available from this repository.

Abstract

A critical discussion is presented about the possible role of Pt–protein interactions in the mechanisms of action of platinum anticancer compounds. Although, since 40 years from its discovery, cisplatin and analogues are believed to exert their therapeutic effects via direct interactions with nucleic acids, several proteins/enzymes have recently appeared to be involved in the compounds' overall pharmacological and toxicological profiles, apart from classical serum transport proteins and metal detoxification systems. As an example, the emerging role of zinc finger proteins is noteworthy in the activity of platinum drugs. Moreover, the pursuit of novel platinum candidates that selectively target enzymes is now the subject of intense investigation in medicinal bioinorganic chemistry and chemical biology. An overview is presented of the most representative studies in the field, with particular focus on the characterization of the Pt–protein interactions at a molecular level, using different biophysical and analytical methods.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Subjects: Q Science > QD Chemistry
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Publisher: Royal Society of Chemistry
ISSN: 2041-6520
Date of Acceptance: 9 July 2012
Last Modified: 04 Jun 2017 08:30
URI: http://orca.cf.ac.uk/id/eprint/79318

Citation Data

Cited 109 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item