Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Conjugation of organoruthenium(II) 3-(1H-Benzimidazol-2-yl)pyrazolo[3,4-b]pyridines and indolo[3,2-d]benzazepines to recombinant human serum albumin: a strategy to enhance Cytotoxicity in Cancer Cells

Stepanenko, Iryna N., Casini, Angela, Edafe, Fabio, Novak, Maria S., Arion, Vladimir B., Dyson, Paul J., Jakupec, Michael A. and Keppler, Bernhard K. 2011. Conjugation of organoruthenium(II) 3-(1H-Benzimidazol-2-yl)pyrazolo[3,4-b]pyridines and indolo[3,2-d]benzazepines to recombinant human serum albumin: a strategy to enhance Cytotoxicity in Cancer Cells. Inorganic Chemistry 50 (24) , pp. 12669-12679. 10.1021/ic201801e

Full text not available from this repository.

Abstract

Five organoruthenium complexes [RuCl(η6-arene)(L)]Cl with a modified arene ligand, namely, 4-formylphenoxyacetyl-η6-benzylamide, and L = 3-(1H-benzimidazol-2-yl)-1H-pyrazolo[3,4-b]pyridines or indolo[3,2-d]benzazepines were synthesized and conjugated to recombinant human serum albumin in order to improve their drug targeting and delivery to cancer cells, and a marked increase in cytotoxicity was observed.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Subjects: Q Science > QD Chemistry
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Publisher: American Chemical Society
Last Modified: 04 Jun 2017 08:30
URI: http://orca.cf.ac.uk/id/eprint/79325

Citation Data

Cited 38 times in Scopus. View in Scopus. Powered By Scopus® Data

Cited 21 times in Web of Science. View in Web of Science.

Actions (repository staff only)

Edit Item Edit Item