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Multinuclear cytotoxic metallodrugs: physicochemical characterization and biological properties of novel heteronuclear gold-titanium complexes

Wenzel, Margot, Bertrand, Benoit, Eymin, Marie-Joelle, Comte, Virginie, Harvey, Jennifer A., Richard, Philippe, Groessl, Michael, Zava, Olivier, Amrouche, Hedi, Harvey, Pierre D., Le Gendre, Pierre, Picquet, Michel and Casini, Angela 2011. Multinuclear cytotoxic metallodrugs: physicochemical characterization and biological properties of novel heteronuclear gold-titanium complexes. Inorganic Chemistry 50 (19) , pp. 9472-9480. 10.1021/ic201155y

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Abstract

A series of titanocene−gold bi- and trimetallic complexes have been prepared and characterized spectroscopically. The luminescence spectroscopy and photophysics of [[(η5-C5H5)(μ-η5:κ1-C5H4PPh2)TiCl2]2Au]PF6 have been investigated, and evidence for interfragment interactions is provided. The cytotoxicity studies of the complexes on A2780 cancer cells and on their cisplatin-resistant cell line showed an activity in the low micromolar range. Cell uptake measurements and interaction studies with plasmid DNA and ubiquitin have been undertaken on some of the compounds.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Subjects: Q Science > QD Chemistry
Publisher: American Chemical Society
Last Modified: 04 Jun 2017 08:30
URI: http://orca.cf.ac.uk/id/eprint/79327

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Cited 27 times in Web of Science. View in Web of Science.

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