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Ruthenium(II) arene complexes with oligocationic triarylphosphine ligands: synthesis, DNA interactions and in vitro properties

Snelders, Dennis J. M., Casini, Angela, Edafe, Fabio, van Koten, Gerard, Gebbink, Robertus J. M. Klein and Dyson, Paul J. 2011. Ruthenium(II) arene complexes with oligocationic triarylphosphine ligands: synthesis, DNA interactions and in vitro properties. Journal of Organometallic Chemistry 696 (5) , pp. 1108-1116. 10.1016/j.jorganchem.2010.11.025

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Abstract

The synthesis, DNA binding properties and cytotoxicity of a series of Ru(II)-arene complexes containing oligocationic ammonium-functionalized triarylphosphines, of the type Ru(p-cymene)Cl2(L) (L = oligocationic phosphine), are reported. The complexes are highly charged (the overall charge states being +3 and +6) and circular dichroism spectroscopy and gel electrophoresis studies indicate that the compounds interact strongly with DNA via electrostatic interactions. Despite forming strong interactions with DNA, the complexes exhibit only modest cytotoxicities on the human ovarian cancer cell lines A2780 and A2780cisR.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Subjects: Q Science > QD Chemistry
Publisher: Elsevier
Date of Acceptance: 17 November 2010
Last Modified: 04 Jun 2017 08:30
URI: http://orca.cf.ac.uk/id/eprint/79330

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