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Thiolato gold(I) complexes containing water-soluble phosphane ligands: a characterization of their chemical and biological properties

Vergara, Elena, Cerrada, Elena, Clavel, Catherine, Casini, Angela and Laguna, Mariano 2011. Thiolato gold(I) complexes containing water-soluble phosphane ligands: a characterization of their chemical and biological properties. Dalton Transactions 40 (41) , pp. 10927-10935. 10.1039/C1DT10892A

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Abstract

A series of thiolate gold(I) derivatives bearing water soluble phosphanes – namely sodium triphenylphosphane monosulfonate (TPPMS), sodium triphenylphosphane trisulfonate (TPPTS), 1,3,5-triaza-7-phosphaadamantane (PTA) and 3,7-diacetyl-1,3,7-triaza-5-phosphabicyclo[3.3.1]nonane (DAPTA) – is reported and the compounds studied for their luminescence properties in the solid state. Two of these derivatives, [Au(SMe2pyrim)(PTA)] and [Au(SBenzoxazole)(DAPTA)], are also structurally characterized by X-ray diffraction analysis. Strong antiproliferative effects are observed for most of the compounds in the human ovarian carcinoma cell lines (A2780/S) and its cisplatin-resistant variant (A2780/R), which depend on both the type of thiolate and phosphane ligands. ICP-MS studies were also performed to evaluate the influence of the gold uptake on the cytotoxic potency of the compounds.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Subjects: Q Science > QD Chemistry
Publisher: Royal Society of Chemistry
Date of Acceptance: 8 August 2011
Last Modified: 04 Jun 2017 08:30
URI: http://orca.cf.ac.uk/id/eprint/79332

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