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The x-ray structure of the adduct between NAMI-A and carbonic anhydrase provides insights into the reactivity of this metallodrug with proteins

Casini, Angela, Temperini, Claudia, Gabbiani, Chiara, Supuran, Claudiu T. and Messori, Luigi 2010. The x-ray structure of the adduct between NAMI-A and carbonic anhydrase provides insights into the reactivity of this metallodrug with proteins. ChemMedChem 5 (12) , pp. 1989-1994. 10.1002/cmdc.201000331

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Abstract

Heavy metals rock! The reactivity of the antimetastatic metallodrug NAMI-A with human carbonic anhydrase II (hCAII) has been investigated using a number of techniques, including X-ray crystallography. The characterization of the interactions between NAMI-A and hCAII provides valuable information on the molecular mechanisms responsible for the activity of this promising anticancer agent.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Subjects: Q Science > QD Chemistry
Publisher: Wiley-Blackwell
ISSN: 1860-7179
Last Modified: 04 Jun 2017 08:30
URI: http://orca.cf.ac.uk/id/eprint/79336

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