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Cytotoxic profile and peculiar reactivity with biomolecules of a novel "rule-breaker" iodidoplatinum(II) complex

Messori, Luigi, Casini, Angela, Gabbiani, Chiara, Michelucci, Elena, Cubo, Leticia, Rios-Luci, Carla, Padron, Jose M., Navarro-Ranninger, Carmen and Quiroga, Adoracion G. 2010. Cytotoxic profile and peculiar reactivity with biomolecules of a novel "rule-breaker" iodidoplatinum(II) complex. ACS Medicinal Chemistry Letters 1 (8) , pp. 381-385. 10.1021/ml100081e

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Abstract

Novel and surprising biological properties were disclosed for the platinum(II) complex cis-diiodidodiisopropylamineplatinum(II). Remarkably, this new platinum(II) complex manifests pronounced antiproliferative properties in vitro, in some cases superior to those of cisplatin. A peculiar reactivity with the model protein cytochrome c was indeed highlighted based on the loss of amine ligands and retention of iodides.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Subjects: Q Science > QD Chemistry
Publisher: American Chemical Society
Last Modified: 04 Jun 2017 08:30
URI: http://orca.cf.ac.uk/id/eprint/79337

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Cited 28 times in Scopus. View in Scopus. Powered By Scopus® Data

Cited 14 times in Web of Science. View in Web of Science.

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