Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Gold(III) compounds as anticancer drugs

Gabbiani, Chiara, Casini, Angela and Messori, Luigi 2007. Gold(III) compounds as anticancer drugs. Gold Bulletin 40 (1) , pp. 73-81. 10.1007/BF03215296

Full text not available from this repository.

Abstract

Gold(III) complexes constitute a new class of metallodrugs, of potential interest for cancer treatment. During the past decade different kinds of gold(III) complexes have been reported to be appreciably stable under physiological-like conditions and to manifest relevant antiproliferative properties against selected human tumor cell lines. Some relevant examples are presented. Recent investigations point out that the interactions of cytotoxic gold(III) complexes with DNA are significantly different and weaker than those of platinum analogues; important interactions with model proteins and target proteins have been reported as well. Accordingly, the mechanisms of action of cytotoxic gold(III) complexes seem to be innovative and substantially different from that of cisplatin. Relevant antimitochondrial effects were demonstrated in some cases, eventually leading to cell apoptosis.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Subjects: Q Science > QD Chemistry
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Publisher: Springer
ISSN: 0017-1557
Last Modified: 04 Jun 2017 08:30
URI: http://orca.cf.ac.uk/id/eprint/79380

Citation Data

Cited 102 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item