Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Sulfonamides and sulfonylated derivatives as anticancer agents

Casini, Angela, Scozzafava, Andrea, Mastrolorenzo, Antonio and Supuran, Claudiu T. 2002. Sulfonamides and sulfonylated derivatives as anticancer agents. Current Cancer Drug Targets 2 (1) , pp. 55-75. 10.2174/1568009023334060

Full text not available from this repository.

Abstract

The sulfonamides constitute an important class of drugs, with several types of pharmacological agents possessing antibacterial, anti-carbonic anhydrase, diuretic, hypoglycemic and antithyroid activity among others. A host of structurally novel sulfonamide derivatives have recently been reported to show substantial antitumor activity in vitro and / or in vivo. Although they have a common chemical motif of aromatic / heterocyclic sulfonamide, there are a variety of mechanisms of their antitumor action, such as carbonic anhydrase inhibition, cell cycle arrest in the G1 phase, disruption of microtubule assembly, functional suppression of the transcriptional activator NF-Y, and angiogenesis (matrix metalloproteinase, MMP) inhibition among others. Some of these compounds selected via elaborate preclinical screenings or obtained based on computer-aided drug design, are currently being evaluated in clinical trials. This review summarizes recent classes of sulfonamides and related sulfonyl derivatives disclosed ultimately as effective tumor cell growth inhibitors, or for the treatment of different types of cancer.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Subjects: Q Science > QD Chemistry
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Publisher: Bentham Science Publishers
ISSN: 1568-0096
Last Modified: 04 Jun 2017 08:30
URI: http://orca.cf.ac.uk/id/eprint/79383

Citation Data

Cited 191 times in Scopus. View in Scopus. Powered By Scopus® Data

Cited 149 times in Web of Science. View in Web of Science.

Actions (repository staff only)

Edit Item Edit Item