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Elacytarabine in relapsed/refractory acute myeloid leukaemia: an evaluation of clinical efficacy, pharmacokinetics, cardiac safety and effects on lipid profile

Knapper, Steven, Chevassut, Timothy, Duarte, Rafael, Bergua, Juan Miguel, Salamero, Olga, Johansen, Malin, Jacobsen, Tove Flem, Hals, Petter-Arnt, Rasch, Wenche, Gianella-Borradori, Athos and Smith, Matthew 2014. Elacytarabine in relapsed/refractory acute myeloid leukaemia: an evaluation of clinical efficacy, pharmacokinetics, cardiac safety and effects on lipid profile. Leukemia Research 38 (3) , pp. 346-351. 10.1016/j.leukres.2013.12.011

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Abstract

Elacytarabine is the elaidic acid ester derivative of cytarabine, designed to enter cells independently of nucleoside transporters. Effects of elacytarabine on QT interval, serum lipid profile and clinical activity were investigated in 43 relapsed/refractory AML patients. Mean maximum increase in corrected QT interval of 24(±29) ms occurred 48 h after elacytarabine infusion without associated arrhythmias or clinical symptoms. A non-clinically significant, elacytarabine exposure-dependent increase in cholesterol was caused by a cholesterol rich lipoprotein depleted of apolipoprotein B formed by infused phospholipids complexing cholesterol. Elacytarabine is clinically active in relapsed/refractory AML: overall response rate (CR + CRi) was 44% (16/36 with 7 non-evaluable patients) and adverse events were manageable.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Publisher: Elsevier
ISSN: 0145-2126
Date of Acceptance: 13 December 2013
Last Modified: 27 Mar 2019 17:02
URI: http://orca.cf.ac.uk/id/eprint/79436

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