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The association of 25-hydroxyvitamin D3 and D2 with behavioural problems in childhood

Tolppanen, Anna-Maija, Sayers, Adrian, Fraser, William D., Lewis, Glyn, Zammit, Stanley and Lawlor, Debbie A. 2012. The association of 25-hydroxyvitamin D3 and D2 with behavioural problems in childhood. PLoS ONE 7 (7) , e40097. 10.1371/journal.pone.0040097

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Abstract

BACKGROUND: Higher serum concentrations of 25-hydroxyvitamin D (25(OH)D), an indicator of vitamin D synthesis and intake, have been associated with better mental health and cognitive function. Concentrations of 1,25-dihydroxyvitamin D(3) (the active vitamin D(3) metabolite) have been associated with openness and extrovert behaviour, but 25(OH)D concentrations have not been associated with behavioural problems in humans. METHODS: We investigated the prospective association between the different forms of 25(OH)D - 25(OH)D(3) and 25(OH)D(2)- and childhood behavioural problems in Avon Longitudinal Study of Parents and Children (ALSPAC). Serum 25(OH)D(3) and 25(OH)D(2) concentrations were assessed at mean age 9.9 years. Incident behavioural problems were assessed with Strengths and Difficulties Questionnaire (SDQ; emotional symptoms, conduct problems, hyperactivity-inattention problems, peer relationship problems and pro-social behaviour subscales and total difficulties score) at mean age 11.7. Sample sizes varied between 2413-2666 depending on the outcome. RESULTS: Higher 25(OH)D(3) concentrations were weakly associated with lower risk of prosocial problems (fully adjusted odds ratio: OR (95% confidence interval: CI) 0.85 (0.74, 0.98)). Serum 25(OH)D(3) or 25(OH)D(2) concentrations were not associated with other subscales of SDQ or total difficulties score after adjusting for concfounders and other measured analytes related to vitamin D. CONCLUSIONS: Our findings do not support the hypothesis that 25-hydroxyvitamin D status in childhood has important influences on behavioural traits in humans.

Item Type: Article
Date Type: Publication
Status: Published
Schools: MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Medicine
Systems Immunity Research Institute (SIURI)
Subjects: R Medicine > R Medicine (General)
Additional Information: Copyright: © 2012 Tolppanen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Publisher: Public Library of Science
ISSN: 1932-6203
Date of First Compliant Deposit: 30 March 2016
Last Modified: 04 Jun 2017 08:31
URI: http://orca.cf.ac.uk/id/eprint/79788

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