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Genetic variation in hyperpolarization-activated cyclic nucleotide-gated channels and its relationship with neuroticism, cognition and risk of depression

McIntosh, Andrew M., Simen, Arthur A., Evans, Kathryn L., Hall, Jeremy, MacIntyre, Donald J., Blackwood, Douglas, Morris, Andrew D., Smith, Blair H., Dominiczak, Anna, Porteous, David, Deary, H. Ian and Thomson, Pippa A. 2012. Genetic variation in hyperpolarization-activated cyclic nucleotide-gated channels and its relationship with neuroticism, cognition and risk of depression. Frontiers in Genetics 3 , p. 116. 10.3389/fgene.2012.00116

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Abstract

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are encoded by four genes (HCN1-4) and, through activation by cyclic AMP (cAMP), represent a point of convergence for several psychosis risk genes. On the basis of positive preliminary data, we sought to test whether genetic variation in HCN1-4 conferred risk of depression or cognitive impairment in the Generation Scotland: Scottish Family Health Study. HCN1, HCN2, HCN3, and HCN4 were genotyped for 43 haplotype-tagging SNPs and tested for association with DSM-IV depression, neuroticism, and a battery of cognitive tests assessing cognitive ability, memory, verbal fluency, and psychomotor performance. No association was found between any HCN channel gene SNP and risk of depression, neuroticism, or on any cognitive measure. The current study does not support a genetic role for HCN channels in conferring risk of depression or cognitive impairment in individuals from the Scottish population.

Item Type: Article
Date Type: Publication
Status: Published
Schools: MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Medicine
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > R Medicine (General)
Additional Information: © 2012 Mcintosh, Simen, Evans,Hall,MacIntyre, Blackwood,Morris, Smith, Dominiczak, Porteous, Deary and Thomson. This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited.
Publisher: Frontiers Media
ISSN: 1664-8021
Date of First Compliant Deposit: 30 March 2016
Last Modified: 04 Jun 2017 08:31
URI: http://orca.cf.ac.uk/id/eprint/79799

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