Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

The functional neuroanatomy of bipolar disorder: a consensus model

Strakowski, Stephen M, Adler, Caleb M, Almeida, Jorge, Altshuler, Lori L, Blumberg, Hilary P, Chang, Kiki D, DelBello, Melissa P, Frangou, Sophia, McIntosh, Andrew, Phillips, Mary L, Sussman, Jessika E and Townsend, Jennifer D 2012. The functional neuroanatomy of bipolar disorder: a consensus model. Bipolar Disorders 14 (4) , pp. 313-325. 10.1111/j.1399-5618.2012.01022.x

Full text not available from this repository.


OBJECTIVES: Functional neuroimaging methods have proliferated in recent years, such that functional magnetic resonance imaging, in particular, is now widely used to study bipolar disorder. However, discrepant findings are common. A workgroup was organized by the Department of Psychiatry, University of Cincinnati (Cincinnati, OH, USA) to develop a consensus functional neuroanatomic model of bipolar I disorder based upon the participants' work as well as that of others. METHODS: Representatives from several leading bipolar disorder neuroimaging groups were organized to present an overview of their areas of expertise as well as focused reviews of existing data. The workgroup then developed a consensus model of the functional neuroanatomy of bipolar disorder based upon these data. RESULTS: Among the participants, a general consensus emerged that bipolar I disorder arises from abnormalities in the structure and function of key emotional control networks in the human brain. Namely, disruption in early development (e.g., white matter connectivity and prefrontal pruning) within brain networks that modulate emotional behavior leads to decreased connectivity among ventral prefrontal networks and limbic brain regions, especially the amygdala. This developmental failure to establish healthy ventral prefrontal-limbic modulation underlies the onset of mania and ultimately, with progressive changes throughout these networks over time and with affective episodes, a bipolar course of illness. CONCLUSIONS: This model provides a potential substrate to guide future investigations and areas needing additional focus are identified.

Item Type: Article
Date Type: Publication
Status: Published
Schools: MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects: R Medicine > R Medicine (General)
Publisher: John Wiley and Sons A/S
ISSN: 1398-5647
Last Modified: 02 Nov 2015 15:32

Citation Data

Cited 196 times in Google Scholar. View in Google Scholar

Cited 238 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item