Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Prefrontal cortical response to emotional faces in individuals with major depressive disorder in remission

Kerestes, Rebecca, Bhagwagar, Zubin, Nathan, Pradeep J., Meda, Shashwath A., Ladouceur, Cecile D., Maloney, Kathleen, Matuskey, David, Ruf, Barbara, Saricicek, Aybala, Wang, Fei, Pearlson, Godfrey D., Phillips, Mary L. and Blumberg, Hilary P. 2012. Prefrontal cortical response to emotional faces in individuals with major depressive disorder in remission. Psychiatry Research: Neuroimaging 202 (1) , pp. 30-37. 10.1016/j.pscychresns.2011.11.004

Full text not available from this repository.


Abnormalities in the response of the orbitofrontal cortex (OFC) and dorsolateral prefrontal cortex (DLPFC) to negative emotional stimuli have been reported in acutely depressed patients. However, there is a paucity of studies conducted in unmedicated individuals with major depressive disorder in remission (rMDD) to assess whether these are trait abnormalities. To address this issue, 19 medication-free rMDD individuals and 20 healthy comparison (HC) participants were scanned using functional magnetic resonance imaging while performing an implicit emotion processing task in which they labeled the gender of faces depicting negative (fearful), positive (happy) and neutral facial expressions. The rMDD and HC groups were compared using a region-of-interest approach for two contrasts: fear vs. neutral and happy vs. neutral. Relative to HC, rMDD showed reduced activation in left OFC and DLPFC to fearful (vs. neutral) faces. Right DLPFC activation to fearful (vs. neutral) faces in the rMDD group showed a significant positive correlation with duration of euthymia. The findings support deficits in left OFC and DLPFC responses to negative emotional stimuli during euthymic periods of MDD, which may reflect trait markers of the illness or a 'scar' due to previous depression. Recovery may also be associated with compensatory increases in right DLPFC functioning.

Item Type: Article
Date Type: Publication
Status: Published
Schools: MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects: R Medicine > R Medicine (General)
Publisher: Elsevier
ISSN: 0925-4927
Last Modified: 28 Oct 2015 09:06

Citation Data

Cited 30 times in Google Scholar. View in Google Scholar

Cited 29 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item