Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Cannabis, schizophrenia and other non-affective psychoses: 35 years of follow-up of a population-based cohort

Manrique-Garcia, E., Zammit, Stanley, Dalman, C., Hemmingsson, T., Andreasson, S. and Allebeck, P. 2012. Cannabis, schizophrenia and other non-affective psychoses: 35 years of follow-up of a population-based cohort. Psychological Medicine 42 (06) , pp. 1321-1328. 10.1017/S0033291711002078

Full text not available from this repository.

Abstract

BACKGROUND: There is now strong evidence that cannabis use increases the risk of psychoses including schizophrenia, but the relationship between cannabis and different psychotic disorders, as well as the mechanisms, are poorly known. We aimed to assess types of psychotic outcomes after use of cannabis in adolescence and variation in risk over time. METHOD: A cohort of 50 087 military conscripts with data on cannabis use in late adolescence was followed up during 35 years with regard to in-patient care for psychotic diagnoses. RESULTS: Odds ratios for psychotic outcomes among frequent cannabis users compared with non-users were 3.7 [95% confidence interval (CI) 2.3-5.8] for schizophrenia, 2.2 (95% CI 1.0-4.7) for brief psychosis and 2.0 (95% CI 0.8-4.7) for other non-affective psychoses. Risk of schizophrenia declined over the decades in moderate users but much less so in frequent users. The presence of a brief psychosis did not increase risk of later schizophrenia more in cannabis users compared with non-users. CONCLUSIONS: Our results confirm an increased risk of schizophrenia in a long-term perspective, although the risk declined over time in moderate users.

Item Type: Article
Date Type: Publication
Status: Published
Schools: MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Medicine
Subjects: R Medicine > R Medicine (General)
Publisher: Cambridge University Press
ISSN: 0033-2917
Last Modified: 04 Jun 2017 08:32
URI: http://orca.cf.ac.uk/id/eprint/79924

Citation Data

Cited 87 times in Google Scholar. View in Google Scholar

Cited 72 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item