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Interobserver agreement in the reporting of colorectal polyp pathology among bowel cancer screening pathologists in Wales

Turner, Jeffrey, Williams, Geraint, Morgan, Meleri, Wright, Melissa and Dolwani, Sunil 2013. Interobserver agreement in the reporting of colorectal polyp pathology among bowel cancer screening pathologists in Wales. Histopathology 62 (6) , pp. 916-924. 10.1111/his.12110

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Abstract

Aims: To assess the interobserver agreement in the reporting of colorectal polyps among histopathologists participating in the Welsh Bowel Cancer Screening (BCS) programme. Methods and results: Twelve benign polyps representative of BCS cases were identified from pathology files and reported by 28 BCS histopathologists using proforma sheets. The level of agreement between the participants and a gold standard was determined using kappa (κ) statistics. A moderate level of agreement was achieved in the reporting of polyp type [κ = 0.45; 95% confidence interval (CI) 0.34-0.59] and adenomatous lesions were distinguished from non-adenomatous lesions in 96% of cases. Substantial agreement was obtained in distinguishing low- and high-grade dysplasias (κ = 0.67; 95% CI 0.50-0.86), but there was only fair agreement in reporting excision margin status (κ = 0.24; 95% CI 0.07-0.43) with frequent use of the 'uncertain' category. Significant issues included categorizing serrated lesions, recognizing focal high-grade dysplasia and epithelial misplacement, and apparent overdiagnosis of villous change in adenomas. Conclusions: Interobserver variability in some aspects of reporting colorectal polyps by BCS pathologists is suboptimal, with a potential impact upon patient management and the efficient running of the screening service.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > RB Pathology
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Uncontrolled Keywords: Adenocarcinoma; Adenoma; Adenomatous Polyps; Colonic Polyps; Colorectal Neoplasms; Early Detection of Cancer; Humans; Hyperplasia; Intestinal Polyps; Observer Variation; Pathology, Clinical; Wales
Publisher: Wiley-Blackwell
ISSN: 0309-0167
Date of Acceptance: 6 February 2013
Last Modified: 04 Jun 2017 08:33
URI: http://orca.cf.ac.uk/id/eprint/80108

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