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Association of the Alzheimer's disease clusterin risk allele with plasma clusterin concentration

Schuermann, Britta, Wiese, Birgitt, Bickel, Horst, Weyerer, Siegfried, Riedel-Heller, Steffi G., Pentzek, Michael, Bachmann, Cadja, Williams, Julie, van den Bussche, Hendrik, Maier, Wolfgang and Jessen, Frank 2011. Association of the Alzheimer's disease clusterin risk allele with plasma clusterin concentration. Journal of Alzheimers Disease 25 (3) , pp. 421-424.

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Abstract

A variant within the clusterin gene has been recently associated with increased risk for Alzheimer's disease (AD) in genome wide association studies. Here we tested the association of the respective single nucleotide polymorphisms (rs11136000) with plasma concentration of clusterin in 67 AD subjects and 191 cognitively unimpaired elderly individuals. We observed an association of the rs11136000 AD-risk variant with low clusterin plasma levels in an allele-dose dependent manner in the healthy individuals (p = 0.011). This effect was numerically also present in the AD patients. We conclude that the rs11136000 AD-risk variant is associated with low clusterin plasma levels.

Item Type: Article
Date Type: Publication
Status: Published
Schools: MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Medicine
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > R Medicine (General)
Publisher: IoS Press
ISSN: 1387-2877
Last Modified: 04 Jun 2017 08:34
URI: http://orca.cf.ac.uk/id/eprint/80470

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