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Imaging small vessel disease: Lesion topography, networks, and cognitive deficits investigated with MRI

O'Sullivan, Michael 2010. Imaging small vessel disease: Lesion topography, networks, and cognitive deficits investigated with MRI. Stroke 41 (10, Su) , S154-S158. 10.1161/STROKEAHA.110.595314

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Abstract

Small vessel disease is a major contributor to the growing burden of cognitive impairment and dementia. In addition to diagnosis, MRI techniques provide a means to investigate mechanisms of cognitive decline. Studies that incorporate diffusion tensor MRI show that variance in cognitive performance is largely accounted for by alterations in brain structure. Unresolved questions about the link between structure and function include: (1) the relative importance of a small number of strategic lesions versus the cumulative effect of multiple lesions; (2) the underlying basis for the characteristic profile of cognitive impairment, with selective deficits of executive function, processing speed and working memory. This update focuses on MRI approaches to these problems and techniques to analyze spatial distribution of damage in relation to the networks that subserve major cognitive functions. Lesion mapping and voxel-based analysis, and the application of diffusion tensor MRI tractography to reconstruct critical white matter projections, are highly promising approaches for improving understanding of the relationship between structure and function and the mechanisms of cognitive decline.

Item Type: Article
Date Type: Publication
Status: Published
Schools: MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Medicine
Psychology
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > R Medicine (General)
Publisher: American Heart Association
ISSN: 0039-2499
Last Modified: 04 Jun 2017 08:34
URI: http://orca.cf.ac.uk/id/eprint/80545

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