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The strength of the genetic effect. Is there room for an environmental influence in the aetiology of schizophrenia?

McGuffin, P, Asherson, P, Owen, Michael John and Farmer, A 1994. The strength of the genetic effect. Is there room for an environmental influence in the aetiology of schizophrenia? British Journal of Psychiatry 164 (5) , pp. 593-599. 10.1192/bjp.164.5.593

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Abstract

The evidence for a genetic contribution to schizophrenia is compelling. However, the pattern of inheritance is complex and it is usually assumed that environmental factors also have a role that will eventually be identified. We argue that this is not necessarily the case. While a hypothesis combining genetic diathesis with environmental stress cannot be disproved, it is also possible that 'non-genetic' factors consist entirely of stochastic events affecting gene expression or structure.

Item Type: Article
Date Type: Publication
Status: Published
Schools: MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Medicine
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > R Medicine (General)
Publisher: Royal College of Psychiatrists
ISSN: 0007-1250
Last Modified: 04 Jun 2017 08:34
URI: http://orca.cf.ac.uk/id/eprint/80550

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