Failure to find linkage between a functional polymorphism in the dopamine D4 receptor gene and schizophrenia

Shaikh, S., Gill, M., Owen, Michael John ORCID: https://orcid.org/0000-0003-4798-0862, Asherson, P., McGuffin, P., Nanko, S., Murray, R. M. and Collier, D. A. 1994. Failure to find linkage between a functional polymorphism in the dopamine D4 receptor gene and schizophrenia. American Journal of Medical Genetics 54 (1) , pp. 8-11. 10.1002/ajmg.1320540104

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Abstract

We report the results of a linkage study in 24 families multiply affected with schizophrenia using a polymorphic DNA sequence encoding the third cytoplasmic loop of the dopamine D4 receptor. Two-point LOD score analyses with a range of single gene models ranging from near dominant to near recessive revealed no evidence for linkage. In addition, we examined the data by non-parametric sib-pair analysis and found no excess sharing of alleles between affected sib-pairs. We therefore conclude that mutations within the dopamine D4 receptor gene do not have a major aetiological role in schizophrenia in our collection of pedigrees

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Medicine Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	R Medicine > R Medicine (General)
Publisher:	Wiley
ISSN:	0148-7299
Last Modified:	31 Oct 2022 09:20
URI:	https://orca.cardiff.ac.uk/id/eprint/80624

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