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The molecular genetics of Alzheimer's disease

Owen, Michael John 1994. The molecular genetics of Alzheimer's disease. Molecular and Cell Biology of Human Diseases Series 1994 (4) , pp. 92-109.

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Abstract

Alzheimer’s disease (AD) is a common disorder whose prevalence rises steeply with age from less than 1% at age 65 years to at least 20% and possibly as high as 36% in the ninth decade (Mortimer, Schuman and French, 1981; Pfeffer, Afifi and Chance, 1987). Neuropathological studies (Tomlinson, Blessed and Roth, 1970) indicate that approximately 50% of cases of severe dementia are due to AD, 20% to multi-infarct dementia (MID) and a further 20% to mixed AD/MID. The senile plaques and neurofibrillary tangles that are characteristically seen in the brains of those dying with AD were first described in 1907 by a Bavarian psychiatrist, Alois Alzheimer. In the last ten years there has been a rapid advance in understanding the molecular events that underlie these neuropathological changes. Some of this work will be briefly discussed here as it forms the background against which recent studies in molecular genetics have taken place

Item Type: Article
Date Type: Publication
Status: Published
Schools: MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Medicine
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > R Medicine (General)
Publisher: Springer Verlag
ISSN: 1470-0573
Last Modified: 04 Jun 2017 08:35
URI: http://orca.cf.ac.uk/id/eprint/80634

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