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Association analysis of NOTCH4 loci in schizophrenia using family and population-based controls

Sklar, P., Schwab, S. G., Williams, Nigel Melville, Daly, M., Schaffner, S., Maier, W., Albus, M., Trixler, M., Eichhammer, P., Lerer, B., Hallmayer, J., Norton, N., Williams, H., Zammit, Stanley, Cardno, A. G., Jones, S. and McCarthy, G. 2001. Association analysis of NOTCH4 loci in schizophrenia using family and population-based controls. Nature Genetics 28 (2) , pp. 126-128. 10.1038/88836

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Abstract

A genetic association between NOTCH4 and schizophrenia has previously been proposed. Unsing all markers previously shown to be associated, we found no evidence for such in three independent family-based samples (n=519 parent-offspring trios), and a case-control sample derived from the same ethnic background as the original observation. These data strongly suggest that NOTCH4 is not a significant susceptibility allele for schizophrenia.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher: Nature Publishing Group
ISSN: 1061-4036
Last Modified: 24 Dec 2017 21:04
URI: http://orca.cf.ac.uk/id/eprint/80790

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Cited 52 times in Web of Science. View in Web of Science.

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