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A linkage study of schizophrenia with DNA markers from the long arm of chromosome 11

Gill, M., McGuffin, P., Parfitt, E., Mant, R., Asherson, P., Vallada, H., Collier, D., Powell, J., Taylor, C., Sargeant, M., Clements, A., Nanko, S., Whatley, S., Murray, R. and Owen, Michael John 1993. A linkage study of schizophrenia with DNA markers from the long arm of chromosome 11. Psychological Medicine 23 (1) , pp. 27-44. 10.1017/S0033291700038824

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We report the results of a collaborative linkage study using 12 polymorphic markers (9 loci) from the long arm of chromosome 11, and 24 families multiply affected with schizophrenia and other closely related disorders. This region is of interest because several families have been reported in which balanced translocations involving 11q apparently co-segregate with psychotic illness. In addition, the dopamine D2 receptor, porphobilinogen deaminase, and tyrosinase genes map within the region studied and may be aetiologically involved in schizophrenia. We have primarily analysed genotypic data by the LOD score method using a range of single gene models. In order to minimize error due to mis-specification of genetic parameters we have analysed data from markers at candidate gene loci by the non-parametric extended sib-pair method in addition to the LOD score method. Our results suggest that most of the region can be excluded from containing a gene of major effect in the aetiology of this disease.

Item Type: Article
Date Type: Publication
Status: Published
Schools: MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > R Medicine (General)
Publisher: Cambridge University Press
ISSN: 0033-2917
Last Modified: 04 Jun 2017 08:36

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