Growth hormone and physiological responses to clonidine in depression

Katona, Cornelius L. E., Healy, David, Paykel, Eugene S., Theodorou, Andreas E., Lawrence, Kevin M., Whitehouse, Andrew, White, Bill and Horton, Roger W. 1993. Growth hormone and physiological responses to clonidine in depression. Psychological Medicine 23 (01) , pp. 57-63. 10.1017/S0033291700038848

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Abstract

Clonidine (1.3 micrograms/kg) was administered to 62 control and 55 depressed patients free of psychoactive drugs for at least 7 days and fasted overnight. Growth hormone (GH), pulse, blood pressure and sedation were measured every 15 min for 1 h before and 2 h after clonidine infusion. GH response did not differ significantly between control and depressed subjects overall or when divided by sex. The systolic hypotensive and sedative responses were blunted in depressed subjects compared with controls; these effects appeared to be secondary to residual antidepressant drugs since the differences were only significant for those depressed subjects with short drug-free intervals. No differences between depressed subjects and controls were seen in diastolic hypotensive or bradycardic responses and no differences in GH, cardiovascular or sedative responses were found between endogenous and non-endogenous depressed subjects.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Medicine
Subjects:	R Medicine > R Medicine (General)
Publisher:	Cambridge University Press
ISSN:	0033-2917
Last Modified:	03 Dec 2015 11:38
URI:	https://orca.cardiff.ac.uk/id/eprint/80815

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