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Association between schizophrenia and homozygosity at the dopamine D3 receptor gene.

Crocq, M A, Mant, R, Asherson, P, Williams, Julie, Hode, Y, Mayerova, A, Collier, D, Lannfelt, L, Sokoloff, P and Schwartz, J C 1992. Association between schizophrenia and homozygosity at the dopamine D3 receptor gene. Journal of Medical Genetics 29 (12) , pp. 858-860. 10.1136/jmg.29.12.858

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Abstract

Disturbances in dopamine neurotransmission have been postulated to underlie schizophrenia. We report data from two independent studies of a BalI polymorphism in the dopamine D3 receptor gene in patients with schizophrenia. In both studies, more patients than controls were homozygous (p = 0.005, p = 0.008). When pooled data were analysed, this difference was highly significant (p = 0.0001) with a relative risk of schizophrenia in homozygotes of 2.61 (95% confidence intervals 1.60-4.26).

Item Type: Article
Date Type: Publication
Status: Published
Schools: MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Medicine
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > R Medicine (General)
Publisher: Journal of medical genetics
ISSN: 1468-6244
Last Modified: 04 Jun 2017 08:36
URI: http://orca.cf.ac.uk/id/eprint/80852

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