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No association between apolipoprotein E polymorphisms and general cognitive ability in children

Turic, D., Fisher, P. J., Plomin, R. and Owen, Michael John 2001. No association between apolipoprotein E polymorphisms and general cognitive ability in children. Neuroscience Letters 299 (1-2) , pp. 97-100. 10.1016/S0304-3940(00)01789-4

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Abstract

In this work we explored the hypothesis that variation in the gene encoding apolipoprotein E (ApoE) is a factor modifying general cognitive ability (g). A case control sample of 101 high g and 101 average g children was scored for ApoE genotypes and two variants in the transcriptional regulatory region of the gene (Th1/E47cs and -491 AT). No evidence of association between these polymorphisms and g was found. We conclude that variation at these loci is not a factor with a measurable impact on general cognitive ability in the healthy population.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher: Limerick : Elsevier Scientific Publishers Ireland
ISSN: 0304-3940
Last Modified: 04 Jun 2017 08:36
URI: http://orca.cf.ac.uk/id/eprint/80899

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