Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Susceptibility locus for Alzheimer's disease on chromosome 10

Myers, A., Holmans, Peter Alan, Marshall, H., Kwon, J., Meyer, D., Ramic, D., Shears, S., Booth, J., DeVrieze, F. W., Crook, R., Hamshere, Marian Lindsay, Abraham, R., Tunstall, N., Rice, Frances, Carty, S., Lillystone, S., Kehoe, P., Rudrasingham, V., Jones, Lesley, Lovestone, S., Perez-Tur, J., Williams, Julie, Owen, Michael John, Hardy, J. and Goate, A. M. 2000. Susceptibility locus for Alzheimer's disease on chromosome 10. Science 290 (5500) , pp. 2304-2305. 10.1126/science.290.5500.2304

Full text not available from this repository.

Abstract

The apolipoprotein E (APOE) gene is the only genetic risk factor that has so far been linked to risk for late-onset Alzheimer's disease (LOAD). However, 50 percent of Alzheimer's disease cases do not carry an APOE4 allele, suggesting that other risk factors must exist. We performed a two-stage genome-wide screen in sibling pairs with LOAD to detect other susceptibility loci. Here we report evidence for an Alzheimer's disease locus on chromosome 10. Our stage one multipoint lod score (logarithm of the odds ratio for linkage/no linkage) of 2.48 (266 sibling pairs) increased to 3.83 in stage 2 (429 sibling pairs) close to D10S1225 (79 centimorgans). This locus modifies risk for Alzheimer's disease independent of APOE genotype.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher: American Association for the Advancement of Science
ISSN: 0036-8075
Last Modified: 02 May 2019 12:47
URI: http://orca.cf.ac.uk/id/eprint/80956

Citation Data

Cited 330 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item