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Serotonergic and dopaminergic mechanisms in graft-induced dyskinesia in a rat model of Parkinson's disease

Shin, Eunju, Garcia, Joanna, Winkler, Christian, Björklund, Anders and Carta, Manolo 2012. Serotonergic and dopaminergic mechanisms in graft-induced dyskinesia in a rat model of Parkinson's disease. Neurobiology of Disease 47 (3) , pp. 393-406. 10.1016/j.nbd.2012.03.038

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Abstract

Dyskinesia seen in the off-state, referred as graft-induced dyskinesia (GID), has emerged as a serious complication induced by dopamine (DA) cell transplantation in parkinsonian patients. Although the mechanism underlying the appearance of GID is unknown, in a recent clinical study the partial 5-HT1A agonist buspirone was found to markedly reduce GID in three grafted patients, who showed significant serotonin (5-HT) hyperinnervation in the grafted striatum in positron emission tomography scanning (Politis et al., 2010, 2011). Prompted by these findings, this study was performed to investigate the involvement of serotonin neurons in the appearance of GID in the rat 6-hydroxydopamine model.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords: Graft-induced dyskinesia; L-DOPA-induced dyskinesia; Parkinson's disease; Serotonin; Dopamine D2 receptor; Cell transplantation
Publisher: Elsevier
ISSN: 0969-9961
Date of Acceptance: 31 March 2012
Last Modified: 04 Jun 2017 08:36
URI: http://orca.cf.ac.uk/id/eprint/81018

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