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Predisposing locus for Alzheimer's disease on chromosome 21

Goate, AlisonM., Owen, Michael John, James, LouiseA., Mullan, MichaelJ., Rossor, MartinN., Haynes, AndrewR., Farrall, Martin, Lai, LawrenceY.C., Roques, Penelope, Williamson, Robert and Hardy, JohnA. 1989. Predisposing locus for Alzheimer's disease on chromosome 21. The Lancet 333 (8634) , pp. 352-355. 10.1016/S0140-6736(89)91725-X

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Linkage between Alzheimer's disease and markers on the long arm of chromosome 21 was investigated in six families affected by disease of early onset. Linkage was confirmed and the disease locus shown to be centromeric to the locus D21S1/S11 on the long arm of the chromosome. It is argued that the data are consistent with the notion that all patients with Alzheimer's disease of genetic aetiology have a predisposing locus on chromosome 21.

Item Type: Article
Date Type: Publication
Status: Published
Schools: MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > R Medicine (General)
Publisher: Elsevier
ISSN: 0140-6736
Last Modified: 04 Jun 2017 08:37

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