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Multiple sclerosis lesions: insights from imaging techniques

Tomassini, Valentina and Palace, Jacqueline 2009. Multiple sclerosis lesions: insights from imaging techniques. Expert Review of Neurotherapeutics 9 (9) , pp. 1341-1359. 10.1586/ern.09.83

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Abstract

The hallmark of multiple sclerosis (MS) pathology is the presence of inflammatory demyelinated lesions distributed throughout the CNS. Along with more diffuse tissue abnormalities, it is considered one of the major determinants of neurological deficit in MS. Conventional MRI has contributed to improve our understanding of MS pathology and has provided objective and reliable measures to monitor the effect of treatments. Advanced MRI techniques have offered the opportunity to quantify pathological changes in lesions, as well as in normal-appearing brain tissue and to characterize their dynamics. This review will discuss the characteristics and development of MS lesions and the contribution of conventional and quantitative MRI techniques to understanding pathological changes associated with them.

Item Type: Article
Date Type: Publication
Status: Published
Schools: MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Medicine
Subjects: R Medicine > R Medicine (General)
Publisher: Expert Reviews
ISSN: 1473-7175
Last Modified: 04 Apr 2020 01:36
URI: http://orca.cf.ac.uk/id/eprint/81467

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