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Life events and depressive symptoms in childhood--shared genes or shared adversity? A research note.

Thapar, Anita, Harold, Gordon Thomas and McGuffin, P 1998. Life events and depressive symptoms in childhood--shared genes or shared adversity? A research note. Journal of Child Psychology and Psychiatry 39 (8) , pp. 1153-1158. 10.1111/1469-7610.00419

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Abstract

A twin study design was used to examine to what extent genetic and environmental factors mediate the association between life events and depressive symptoms. Questionnaire measures (maternally rated) of depressive symptoms and life events were obtained for a systematically ascertained sample of 270 twin pairs aged 8 to 17 years. Bivariate genetic model fitting showed that depressive symptoms and some life events (total events, negative impact) share a common genetic influence. The covariation of independent life events and depressive symptoms was explained by a shared environmental influence common to both. At least part of the association between life events and depressive symptoms is mediated by familial factors that include both genes and shared environment.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher: Wiley-Blackwell
ISSN: 0021-9630
Last Modified: 24 Dec 2017 21:19
URI: http://orca.cf.ac.uk/id/eprint/81553

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