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Advances in broad bandwidth light sources for ultrahigh resolution optical coherence tomography

Unterhuber, A, Pova ay, B, Bizheva, K, Hermann, B, Sattmann, H, Stingl, A, Le, T, Seefeld, M, Menzel, R, Preusser, M, Budka, H, Schubert, Ch, Reitsamer, H, Ahnelt, P K, Morgan, James Edwards, Cowey, A and Drexler, W 2004. Advances in broad bandwidth light sources for ultrahigh resolution optical coherence tomography. Physics in Medicine and Biology 49 (7) , pp. 1235-1246. 10.1088/0031-9155/49/7/011

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Abstract

Novel ultra-broad bandwidth light sources enabling unprecedented sub-2 microm axial resolution over the 400 nm-1700 nm wavelength range have been developed and evaluated with respect to their feasibility for clinical ultrahigh resolution optical coherence tomography (UHR OCT) applications. The state-of-the-art light sources described here include a compact Kerr lens mode locked Ti:sapphire laser (lambdaC = 785 nm, delta lambda = 260 nm, P(out) = 50 mW) and different nonlinear fibre-based light sources with spectral bandwidths (at full width at half maximum) up to 350 nm at lambdaC = 1130 nm and 470 nm at lambdaC = 1375 nm. In vitro UHR OCT imaging is demonstrated at multiple wavelengths in human cancer cells, animal ganglion cells as well as in neuropathologic and ophthalmic biopsies in order to compare and optimize UHR OCT image contrast, resolution and penetration depth.

Item Type: Article
Date Type: Publication
Status: Published
Schools: MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Medicine
Subjects: R Medicine > R Medicine (General)
Publisher: IOP Publishing
ISSN: 0031-9155
Last Modified: 04 Jun 2017 08:38
URI: http://orca.cf.ac.uk/id/eprint/81695

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