Molecular genetic studies of cognitive ability

Daniels, J., McGuffin, P., Owen, Michael John ORCID: https://orcid.org/0000-0003-4798-0862 and Plomin, R. 1998. Molecular genetic studies of cognitive ability. Human Biology 70 (2) , pp. 281-296.

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Abstract

Given that the evidence of a substantial genetic contribution to cognitive ability is now convincing, the next challenge is to locate and identify the genes involved. It is likely that there are several genes, each of only small effect. Detection of such so-called quantitative trait loci contributing to polygenic traits in plants and animals is facilitated by the ability to carry out experimental crosses. However, in humans detection of quantitative trait loci depends on studies of siblings or other relative pairs or on allelic association studies aimed at detecting linkage disequilibrium in populations. The allelic association approach is currently being applied to investigate cognitive ability by using both candidate genes and DNA pooling methods that potentially allow rapid screening of the whole genome for quantitative trait loci.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher:	Wayne State University Press
ISSN:	0018-7143
Last Modified:	31 Oct 2022 09:36
URI:	https://orca.cardiff.ac.uk/id/eprint/81714

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